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Similarities to a living cell
- The cell internal environment is very different from the external environment (mobile phase);
- The pore walls form the dimensions and structure of the liquid separation cell;
- The cell internal environment has stationary (bound) and exchangeable (mobile) components;
- The pH and ionic strength inside the cell differs from outside the cell;
- The pore opening acts as a membrane channel for the analytes;
- The cell responds to changes in external environment with physical and chemical changes
- These changes include conformational changes in the long hydrophobic and hydrophilic chains, degree of ionization, charge distribution and counter-ion properties.
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