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Pharmaceutical Analysis - Structural Analysis |
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Our range of mass spectrometers coupled to both HPLC and GC are used to assist clients identify, characterise and, when required, quantify unknowns.
Some examples are cited below: |
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| Characterisation of Product or Process related Impurities or Degradants |
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- Preparative HPLC is used to isolate and concentrate the impurity of interest
- Molecular or Pseudomolecular weight information may not provide adequate information on either the structure or empirical formula of the analyte
- High resolution LCMS is employed to elucidate elemental composition and Tandem LCMS techniques may be used for structural information via collisionally induced dissociation
- GC-MS may be used where the impurity is volatile and library matching is combined with spectral interpretation for a tentative match
- Other techniques such as Solids Probe Electrospray MS and/or Pyrolysis/GC-MS may be used for involatile analytes unsuited to traditional HPLC or GC Analysis
- NMR analysis can also be undertaken to confirm molecular structure of the isolated impurities where required
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