Chromatography Consumables, Analytical Services and Chromatography / Mass Spectrometry Training from Crawford Scientific
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Other Courses


 
 Solid Phase Extraction Training
Capillary Electrophoresis Training
ICP-MS Training

Solid Phase Extraction Training

This course is designed to cover the basic operating and theoretical principles of using liquid chromatography coupled with a mass spectrometer. It will be most useful to those who have a working knowledge of LC-MS but wish to understand the principles that govern the technique.

A comprehensive course designed to increase expertise and optimise method development time for all users of solid phase extraction as a means of sample preparation.

Topics include:
  • Characteristics of Sorbent and Sorbent Selection
  • Covers all steps including:
    • Sample pre-treatment
    • Column Conditioning
    • Column Equilibration
    • Sample Loading
    • Interference Elution
    • Analyte Elution
  • Importance of column conditioning
  • The impact of PH
  • Impact of elution soak steps and solvent strength
  • Selection of the bonded phase and bed mass
  • Significance of secondary interactions and the use of mixed mode approaches
  • Ion-exchange and impact of ionic strength
  • Normal phase extractions
  • Stacked phase approaches
  • Experiments in method development and optimisation
For more information on Solid Phase Extraction Training Courses – click here
 



Capillary Electrophoresis Training

This course is designed to cover the basic operating and theoretical principles of gas chromatography using mass selective detection. It will be most useful to those who have a working knowledge of GC-MS but wish to understand the principles that govern the technique.

Basic Principles of CE
  • Hardware requirements
  • Fundamental properties of ionised and non-ionised species in CE
  • Injection modes (hydrodynamic vs electrokinetic injection)
  • Detection methods - (Direct UV and Indirect UV, diode array UV)
  • Separation modes - (CZE capillary zone, MEKC micellar electrokinetic, CEC capillary electrochromatography, CCE chiral capillary electrochromatography)
  • Detection modes - (qualitative and quantitative detection)
Applications
  • Analysis of Acidic, Basic and Neutral Compounds by CEC.
  • Drugs of Abuse using MEKC.
  • Basic Drugs using PVA-Coated Capillaries.
  • Organic Acid Analysis using Indirect UV Detection.
  • Inorganic Anion Analysis using Indirect UV Detection.
Capillary Technology
  • Packed Capillaries.
  • PVA Coated Capillaries.
  • Summit NaAMPS Capillaries.
Troubleshooting
  • Current loss
  • Baseline Drift
  • Irregular Peaks
  • Tailing Peaks
  • Poor Resolution
  • Shifting Migration Times
  • Poor Reproducibility
For more information on Capillary Zone Separations courses – click here


An Introduction to ICP-MS

This one-day course introduces delegates to the fundamental concepts and principles associated with ICP-MS. Topics covered allow the ICP-MS user to gain a useful insight into the operating principles of the instrument

This course is ideally tailored towards either the experienced user who is looking for a refresher course or towards a new user who is looking for an introduction to the analytical technique.

An introduction to ICP-MS
  • What Can ICP-MS Do?
  • Schematic Design
  • Inductively Coupled Plasmas
  • Sample Introduction
The Mass Spectrometer
  • The Vacuum & Interface Systems
  • Ion Lenses
  • Quadrupole Mass Analyser
  • Detectors
Interferences in ICP-MS
  • Spectrometric Effects
  • Non-Spectrometric Effects
Optimisation
  • Parameter Optimisation
  • Cold Plasma Operating Conditions
Quantitation Techniques
  • Qualitative Analysis
  • Semi-quantitative Analysis
  • Quantitation Strategy
For more information on ICP-MS courses – click here


 
  
 
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